Faculty of the Genetics Program by Department
Anesthesiology
Dubnau, Josh, Learning, memory, genetics, and behavior
Enikolopov, Grigori, Stem cells, neurogenesis, and signal transduction
Biochemistry and Cell Biology
Bingham, Paul, Novel approaches to cancer chemotherapy; genetic control of development and gene expression in animals
Citovsky, Vitaly, Genetic transformation, intercellular transport, and chromatin remodeling in plants
Gergen, J. Peter, Transcriptional regulation in Drosophila
Hu, Chi-Kuo, The biology of dormancy and its interaction with development and aging
Karzai, A. Wali, Structure and function of RNA-binding proteins; SmpB-SsrA quality control system
Luk, Ed, Cellular organization of chromatin structure for accommodation and control of gene expression
Martin, Benjamin, Stem cell maintenance and differentiation; developmental mechanisms of cancer pathogenesis
Neiman, Aaron, Vesicle trafficking and membrane-cytoskeletal interactions
Nelson, Jonathan, Understanding the impact of retrotransposons and repetitive DNA maintenance in germline genome stability
Pisconti, Dada, Muscle stem cells; muscular dystrophy; muscle development; muscle regeneration; muscle aging; extracellular matrix; biology of proteoglycans
Thomsen, Gerald, The transforming growth factor-ß family in embryonic development
Zachar, Zuzana, Cancer chemotherapy drug discovery
Biomedical Engineering
Josephs, Eric, Molecular engineering of CRISPR systems for applications in personalized gene therapies, diagnostics, and antiviral biotechnologies; molecular mechanisms of viral and bacterial mutation
Ecology and Evolution
Davalos, Liliana, Environmental change and its relationship to phylogeny, population genetics, and biodiversity conservation
Eanes, Walter, Molecular evolution and phylogenetic analysis
Rest, Joshua, Computational, comparative, and experimental approaches to study linkage of genotype and phenotype
Veeramah, Krishna, Evolutionary genomics
Weissman, Jackie Lee, Metagenomics and comparative genomics; microbial ecology and evolution; bioinformatics; computational biology
Family, Population, and Preventive Medicine
Williams, Jennie, Cancer chemotherapuetics; cancer health disparity; tumor biology; chemoresistance/chemoresponse in racial and ethnic populations
Medicine
Bahou, Wadie,Genetic disorders of hemostasis and thrombosis
Bialkowska, Agnieszka, Acute and chronic pancreatitis; pancreatic cancer; animal models; pancreatic stromal and immune cell interactions; single-cell and bulk next-generation sequencing
Canals, Daniel, Lipid signaling and metabolism in cancer
Ghebrehiwet, Berhane, Structure-function of C1q receptors and their role in infection, inflammation, and cancer
Hannun, Yusuf, Mechanisms and functions of bioactive sphingolipids in cancer
Zhan, Huichun, The intersection of clonal hematopoiesis, bone marrow immune microenvironment, and cardiovascular diseases
Microbiology and Immunology
Carpino, Nicholas, Positive and negative regulation of T cell receptor signaling
Carter, Carol A., Retroviral assembly and post-assembly events
Del Poeta, Maurizio, Sphingolipid metabolism and signaling in fungal and mammalian cells
Devarajan, Priyadharshini, Enhancing lung and nasal immune defense against respiratory viruses; harnessing T cell memory for enhanced protection; bolstering aged immune responses to combat infections; development of vaccines targeting respiratory pathogens
Futcher, A. Bruce, Cancer, cell cycle, cyclins, microarrays, computational biology, and yeast genetics
Kim, Hwan, Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses
Konopka, James, Genetic analysis of the fungal pathogen Candida albicans
Mackow, Erich, Rotavirus and hantavirus genetics and pathogenesis
Reich (Marshall), Nancy, Signaling switches in gene expression by hormones or viral infection
Sheridan, Brian, Mucosal immunology; T cell memory; vaccine design; host-pathogen interactions
Thanassi, David, Secretion of bacterial virulence factors and their roles in pathogenesis
Van der Velden, Adrianus, The mammalian T cell response to Salmonella enterica serovar Typhimurium
Neurobiology and Behavior
Ge, Shaoyu, Functional integration of new neurons into brain circuits
Kernan, Maurice, Mechanical senses in Drosophila; ciliary signaling
Kritzer, Mary, Effects of the gonadal hormones on the structure, biochemistry, and function of the cerebral cortex
Shelly, Maya, Molecular mechanisms of embryonic brain development; axon regeneration; neurodegenerative disorders
Sher, Roger, Neurobiology; neurodegenerative diseases; amyotrophic lateral sclerosis; Alzheimer's; dementias
Sirotkin, Howard, Genetic and environmental regulation of neurogenesis; neurological disorders including autism and epilepsy
Pathology
Chen, Jiang, Planar cell polarity and primary cilia in skin and hair follicle development and skin cancers
Chung, Jun, Mechanisms of tumor invasion and metastasis
Damaghi, Medhi, Tumor evolution in its microenvironment using single-cell multi omics and spatial omics connecting genotype to phenotype
Furie, Martha B., Interactions of bacterial pathogens with host cells of innate immunity
Ju, Jingfang, miRNAs in proliferation, cell-cycle control, chemoresistance of tumor stem cells, and epithelial-to-mesenchymal transition
Martinez, Luis, Gain of function of mutant p53 oncogene
Moll, Ute, The p53/p73/p63 gene family in human cancer; transcription-independent mitochondrial apoptosis program of p53
Powers, R. Scott, Cancer gene discovery; cancer diagnostics and therapeutics; cancer biology
Shields, Mario, Mechanisms of development and progression of pancreatitis and pancreatic cancer; tissue homeostasis; G-protein signaling; tumor inflammation and metabolism
Shroyer, Kenneth, Molecular characterization of benign, premalignant, and malignant lesions of the female genital tract
Talos, Flaminia, Intra-tumor heterogeneity in prostate cancer; tissue reprogramming in the urinary bladder
Pharmacological Sciences
Bogenhagen, Daniel, Mitochondrial molecular biology
Brownlee, Christopher, Molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation, and axonogenesis
Colognato, Holly, Extracellular matrix in the brain: roles during development and neurodegeneration
Demple, Bruce, Cellular systems to counteract oxidative damage
Frohman, Michael, Lipid signaling in normal physiology, diabetes, and cancer
Kim, Hyungjin, Mechanisms of mammalian DNA replication and repair in cancer development and therapy
Malbon, Craig, Signal transduction in differentiation and development: roles of molecular scaffold molecules
Misra, Jyoti, Regulation of growth in development and cancer by Hippo signaling
Rahme, Gilbert, Cancer epigenetics with a focus on brain tumors
Seeliger, Jessica, Mechanisms of cell wall and membrane assembly in Mycobacterium tuberculosis
Seeliger, Markus, Molecular mechanisms of protein kinase and ubiquitin ligase signaling in cancer and aging
Takemaru, Ken-Ichi, Cell signaling and ciliogenesis in mammalian development, health, and disease
Tan, Dongyan, Epigenetics, chromatin structure and function in transcription and DNA damage repair
Wan, Ledong, RNA metabolism; inflammation; cancer
Physiology and Biophysics
Acosta-Martinez, Maricedes, Neuroendocrine regulation of the hypothalamus-pituitary-gonad (HPG) axis
Cheung, Leonard, Genetic control of pituitary cell fate throughout life using animal and pluripotent cell models and single-cell technologies
Lin, Richard, Physiological functions and pathological roles of phosphoinositide 3-kinases (PI3Ks)
Luberto, Chiara, Sphingolipid metabolism and signaling
White, Thomas, Gap junction functions defined by genetic diseases and gene knockouts
Brookhaven National Laboratory
Freimuth, Paul, Virus-receptor interactions
Cold Spring Harbor Laboratory
Amor Vegas, Corina, Cellular senescence and immune surveillance in cancer and aging
Beyaz, Semir, Dietary regulation of immunity and cancer; epigenetics; metabolism
Cheadle, Lucas, Neuro-immune mechanisms of brain development and disease
Dobin, Alexander, Computational multi-omics; biological big data; bioinformatics tools
dos Santos, Camila, Epigenetic dependencies of normal and malignant breast development; gene expression in prevention and treatment of cancer
Egeblad, Mikala, Tumor microenvironment, tumor-associated myeloid cells, and breast cancer
Fearon, Douglas, Cancer immunology; immunotherapy; host response to cancer
Gingeras, Thomas, Genome-wide organization of transcription and functional roles of non-protein coding RNAs
Hammell, Christopher, Genetic regulation of temporal development and the function of animal microRNAs
Hammell, Molly, Computational and functional genomics; control of transposable elements; neurodegenerative disease
Jackson, David, Plant development; stem cell signaling; genomics and imaging
Janowitz, Tobias, Host response to cancer: metabolic, endocrinological, neurological, and immunological consequences and treatment strategies in cancer medicine
Joshua-Tor, Leemor, Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography
Koo, Peter, Computational biology; artificial intelligence; interpretable deep learning for genomics
Krainer, Adrian R., Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases
Li, Bo, Glutamatergic synapses; synaptic plasticity; schizophrenia; depression; rodent models of psychiatric disorders
Lukey, Michael, Metabolic reprogramming during tumorigenesis and metastasis
Martienssen, Robert, Epigenetics; chromatin and chromosome biology; stem cells; plant genomics; plant evolution; aquatic plants
McCombie, Richard, Genomics of psychiatric disorders; genomics of cancer; computational genomics; plant genomics
Meyer, Hannah, Tolerance induction and generation of diversity in the developing immune system; systems immunology; transcriptomics; bioinformatics
Mills, Alea, Cancer; development; aging; senescence; epigenetics; autism
Pedmale, Ullas, Organism-environment interactions; photobiology; signal transduction; genomics; cellular growth; decision-making in plants
Schorn, Andrea, Non-coding and small RNA; transposable elements; stem cells; epigenetics
Siepel, Adam, Computational biology; population genetics; computational genomics; molecular evolution; transcriptional regulation
Spector, David, Cell biology; gene expression; nuclear structure; non-coding RNAs
Stillman, Bruce, Cancer; cell cycle; DNA replication; chromatin assembly; biochemistry; yeast genetics
Tollkuhn, Jessica, Regulation of gene expression in the brain by estrogen and testosterone
Tonks, Nicholas, Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function
Trotman, Lloyd, Animal models for metastatic cancer therapy and analysis; 3D organ imaging; diet and oxidative cell death mechanisms; the cancer-neuro interface
Tuveson, David, Pancreatic cancer; experimental therapeutics; diagnostics; mouse models; cancer genetics
Vakoc, Christopher, Transcriptional regulation of mammalian cell growth
Van Aelst, Linda, Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development
Westcott, Peter, Cancer genomics and immunology; Evolution of immune surveillance and dysfunction during cancer progression and metastasis
Zhang, Lingbo, Normal and malignant stem and progenitor cells; self-renewal; metabolism; therapeutic targets