Yue Zhang, Ph.D.
yue.zhang@stonybrook.edu
Laboratory of Dr. James Bliska
Ph.D., 1999, Stony Brook University
Select Publications:
Zhang Y, Tam JW, Mena P, van der Velden AW, and JB Bliska. 2015. CCR2+ inflammatory dendritic
cells and translocation of antigen by type III secretion are required for the exceptionally
large CD8+ T cell response to the protective YopE69-77 epitope during Yersinia infection.
PLoS Pathog. 11(10):e1005167. PMID: 26468944
Zhang Y, Mena P, Romanov G, and JB Bliska. 2014. Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection. Infect. Immun. 82(7):3033-3044. PMID: 24799630
McPhee JB, Mena P, Zhang Y, and JB Bliska. 2012. Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect. Immun. 80:2519-2527. PMID: 22547545
Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, and JB Bliska. 2012. A protective epitope in the type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis. Infect. Immun. 80:206-214. PMID: 22064714
Zhang Y, Romanov G and JB Bliska. 2011. Type III secretion system-dependent translocation of ectopically expressed Yop effectors into macrophages by intracellular Yersinia pseudotuberculosis. Infect. Immun. 79:4322-4331. PMID: 21844228
Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, and JB Bliska. 2011. A Yersinia effector with enhanced inhibitory activity on the NF-kB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog. 7(4):e1002026. PMID: 21533069
Zhang Y and JB Bliska. 2011. Mathematical relationship between cytokine concentrations and pathogen levels during infection. Cytokine. 53:158-162. PMID: 21093285
Zhang Y and JB Bliska. 2010. YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection. Infect. Immun. 78:2329-2341. PMID: 20231414
Zhang Y, Murtha J, Roberts MA, Siegel RM, and JB Bliska. 2008. Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages. Infect. Immun. 76:4299-4310. PMID: 18591234
Zhang Y, Ting AT, Marcu KB, and JB Bliska. 2005. Inhibition of MAPK and NF-kappaB pathways is necessary for rapid apoptosis in macrophages infected with Yersinia. J. Immunol. 174:7939-7949. PMID: 15944300
Zhang Y and JB Bliska. 2005. Role of macrophage apoptosis in the pathogenesis of Yersinia. Curr. Top. Microbiol. Immunol. 289:151-173. PMID: 15791955
Zhang Y and JB Bliska. 2003. Role of Toll-like receptor signaling in the apoptotic response of macrophages to Yersinia infection. Infect. Immun. 71:1513-1519. PMID: 12595470
Zhang Y. 2002. Rapid Amplification of cDNA Ends. Generation of cDNA libraries P13-22. Edited by Ying, S. Y., Humana Press Inc., Totowa, NJ. PMID: 12703729
Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, and MA Frohman. 2000. Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. J. Biol. Chem. 275:35224-35232. PMID: 10926929
Frohman MA, Kanaho Y, Zhang Y, and AJ Morris. 2000. Regulation of phospholipase D1 activity by Rho GTPases. Methods Enzymol. 325:177-189. PMID: 11036603
Zhang Y and MA Frohman. 2000. Using rapid amplification of cDNA ends (RACE) to obtain full-length cDNAs. Nucleic Acids Protocols Handbook P 267-288. Edited by Rapley, R., Humana Press Inc., Totowa, NJ. PMID: 22547545
Zhang Y, Altshuller YM, Hammond SM, Hayes F, Morris AJ and MA Frohman. 1999. Loss of receptor regulation by a phospholipase D1 mutant selectively unresponsive to protein kinase C. EMBO J. 18:6339-6348. PMID: 10562546
Yamazaki M, Zhang Y, Watanabe H, Yokozeki T, Ohno S, Kaibuchi K, Shibata H, Mukai H, Ono Y, Frohman MA, and Y Kanaho. 1999. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J. Biol. Chem. 274:6035-6038. PMID: 10037681
Sung TC, Zhang Y, Morris AJ, and MA Frohman. 1999. Structural analysis of human phospholipase D1. J. Biol. Chem. 274:3659-3666. PMID: 9920915
Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, and MA Frohman. 1997. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J. 16:4519-4530. PMID: 9303296
Zhang Y and MA Frohman. 1998. Cloning cDNA ends using RACE. Methods Mol. Med. 13:81-105. PMID: 21390839
Zhang Y and MA Frohman. 1997. Using rapid amplification of cDNA ends (RACE) to obtain full-length cDNAs. Methods Mol. Biol. 69:61-87. PMID: 9116864
Huang H, Tudor M, Su T, Zhang Y, Hu Y, and H Ma. 1996. DNA binding properties of two Arabidopsis MADS domain proteins: binding consensus and dimmer formation. Plant Cell. 8:81-94. PMID: 8597661